Abstract
ObjectiveTo explore the analgesic effects of different concentrations of ropivacaine in transversalis fascia plane (TFP) block during laparotomy.MethodsNinety patients who underwent laparotomy admitted to our hospital from March 2019 to March 2020 were selected as the study subjects and were divided equally into a low concentration group, a medium concentration group, and a high concentration group according to the randomized grouping method. The low concentration group adopted 0.4% ropivacaine 40 ml, the medium concentration group was given 0.5% ropivacaine 40 ml, and the high concentration group was given 0.6% ropivacaine 40 ml. The hemodynamic indexes and the incidence of adverse reactions in the two groups were compared. The Numerical Rating Scale (NRS) was used to assess the postoperative pain in the three groups, the Bruggrmann comfort scale (BCS) was used to assess the comfort level in the three groups, and the Mini-mental State Examination (MMSE) was used to evaluate the postoperative cognitive function of the three groups of patients.ResultsThe mean artery pressure (MAP) and heart rate (HR) levels at T1 and T2 were significantly lower in the medium concentration group than in the other two groups (P < 0.05). The low concentration group had a significantly higher NRS score at T2 than the medium concentration group and the high concentration group (P < 0.05). A significantly higher BCS score was observed in the high concentration group than the other two groups (P < 0.05). There were significantly higher Ramsay scores and MMSE scores in the medium concentration group than in the low concentration and high concentration groups (P < 0.05). The overall incidence of adverse reactions of the high concentration group was significantly higher than that of the low concentration group (P < 0.05), but showed similar results with the medium concentration group.ConclusionThe medium concentration group exhibits a better analgesic effect than the low concentration group and higher safety than the high concentration group. Therefore, the use of medium concentration ropivacaine in TFP block may provide a referential basis for clinical treatment.
Highlights
Gastric diseases, duodenal diseases, and diseases of the hepatobiliary system all require laparotomy [1, 2]
To further investigate the variability of the analgesic effect of different concentrations of ropivacaine in transversalis fascia plane (TFP) block during laparotomy, 90 patients who underwent open surgeries admitted to our hospital from March 2019 to March 2020 were selected as study subjects, and the results are summarized as follows
All enrollments were randomized the ratio of sample size of the three groups was 1:1:1 into a low concentration group, a medium concentration group, and a high concentration group according to the random grouping method
Summary
Duodenal diseases, and diseases of the hepatobiliary system all require laparotomy [1, 2]. Postoperative analgesia conforms to the concept of comfort care and facilitates the prognosis of patients. 40 ml of ropivacaine at a concentration of 0.4% has been mostly applied for transversalis fascia plane (TFP) block in open surgeries, with significant analgesic effect. The impact of variation in the concentration of ropivacaine on analgesic effect and duration of analgesia requires further investigation [7,8,9]. To further investigate the variability of the analgesic effect of different concentrations of ropivacaine in TFP block during laparotomy, 90 patients who underwent open surgeries admitted to our hospital from March 2019 to March 2020 were selected as study subjects, and the results are summarized as follows
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