Abstract
Current use of commonly prescribed or over the counter non-steroidal anti-inflammatory drugs (NSAIDs) for pain and/or osteoarthritis have been limited due to their untoward gastrointestinal and cardiovascular related side effects, as a result the need for a safe and effective alternative has become unequivocally crucial. Analgesic activity of UP446, a standardized bioflavonoid composition with primarily baicalin and (+)-catechin which has been used in both joint supplements and a prescription medical food was evaluated. This natural flavonoid composition reduces production of eicosanoids through dual inhibition of COX and LOX enzymes and also decreases gene expression and protein levels of pro-inflammatory cytokines, IL-1β, IL-6, and TNF-α.
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