Abstract
BackgroundSynedrella nodiflora is used by traditional healers in Ghana for the management of epilepsy and pain. The hydro-ethanolic extract of the whole plant has demonstrated antinociceptive effect in various animal models of pain. This study investigated the potential benefit of the hydro-ethanolic extract in a rat model of paclitaxel-induced neuropathic pain.MethodsNeuropathy was induced in rats by a continuous intraperitoneal administration of paclitaxel (2 mg/kg) for 5 days. Baseline latencies to thermal pain were recorded before the first injection of paclitaxel and during the 5 day induction period. Following the induction, the rats in designated treatment group were treated with the hydro-ethanolic extract (100, 300 and 1000 mg/kg, p.o) or pregabalin (10, 30 and 100 mg/kg) or vehicle (distilled water) and their responses to thermal hyperalgesia measured every 30 for a total period of 3 h.ResultsThere was a significant difference between the baseline reaction latency and what was observed on the 5th day of the induction of neuropathy. Two days after the induction of neuropathy, the extract and pregabalin significantly and dose-dependently produced antinociceptive effect during the 3-h test period.ConclusionThe hydro-ethanolic extract of the whole plant of Synedrella nodiflora possess analgesic effect in paclitaxel-induced neuropathy in rats.
Highlights
Synedrella nodiflora is used by traditional healers in Ghana for the management of epilepsy and pain
Induction of neuropathy Clinical observation of the rats during the 5-day induction of neuropathy with paclitaxel revealed the absence of any ill-health such as alopecia, diarrhoea or weight loss
An assessment of the reaction latencies to thermal pain during the induction period yielded a gradual decline of the latencies from day 0 to day 5
Summary
Synedrella nodiflora is used by traditional healers in Ghana for the management of epilepsy and pain. The hydro-ethanolic extract of the whole plant has demonstrated antinociceptive effect in various animal models of pain. This study investigated the potential benefit of the hydro-ethanolic extract in a rat model of paclitaxel-induced neuropathic pain. In developing countries and some developed countries, the use of plants and plant-based therapies are gradually becoming the alternative sources of medicines for orthodox drug-resistant diseases. These agents are usually the only remedy in areas where access to primary health care is difficult or expensive. The present study was conducted to provide additional pharmacological information regarding the analgesic effect of the hydro-ethanolic extract of the whole plant of Synedrella nodiflora in painful paclitaxel-induced peripheral neuropathy
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