Analgesic Effect of Valerian Root and Turnip Extracts.

Zahra Sobhani,Afshin Zare,Zabihollah Khaksar,Masood Amini

doi:10.29252/wjps.7.3.345

Zahra Sobhani, Afshin Zare + Show 2 more

Open Access

https://doi.org/10.29252/wjps.7.3.345

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Abstract

BACKGROUNDMedicinal plants are considered as one of the important sources of chemical substances with therapeutic effects. This study aimed to compare the analgesic effects of alcoholic extract of valerian root and turnip in rats. METHODSFifty female Wistar rats weighing 190 g were divided into 5 equal groups of control (subcutaneous injection of 2.5% formalin in the right foot), sham (subcutaneous injection of 2.5% formalin+distilled water), experimental 1 (subcutaneous injection of 2.5% formalin+200 mg/kg turnip extract), experimental 2 (subcutaneous injection of 2.5% formalin 2+200 mg/kg valerian root extract) and experimental 3 (subcutaneous injection of 2.5% formalin+200 mg/kg turnip extract+200 mg/kg valerian root extract). The time duration of 0-5 and 16-60 minutes after injection of formalin were respectively considered as acute and chronic phases. Injection of distilled water and the extracts was conducted 30 minutes before assessing the analgesic effects. RESULTSA significant decrease in pain score in the acute phase was observed in the group received valerian root extract compared to the control group. Also, a significant reduction in pain score was noted in the acute and chronic phases of the group receiving simultaneous administration of valerian root and turnip extracts when compared to the control group. CONCLUSIONSimultaneous use of valerian root and turnip extracts is recommended for analgesic effects in both acute and chronic phases of the pain.

Highlights

Since control of pain and its complications are important issue in surgical interventions, several and various researches were performed worldwide to find the best way to deal with pain reduction
A significant decrease in pain score in the acute phase was observed in the group received valerian root extract compared to the control group
A significant reduction in pain score was noted in the acute and chronic phases of the group receiving simultaneous administration of valerian root and turnip extracts when compared to the control group

Summary

Introduction

Since control of pain and its complications are important issue in surgical interventions, several and various researches were performed worldwide to find the best way to deal with pain reduction. 346 Valerian and turnip analgesic effect known, while a large number of medications have been used to control these pathways[1,2,3,4] and among them, opioid analgesics have been widely used.[5] it should be borne in mind that these medicines induce tolerance and dependences too, and can cause incidence of unwanted effects; so necessary caution should be undertaken when they are taken by a patient.[6,7] These medicines control pain by affecting the central parts of the body. Nowadays due to the ease of access to these medicines, there is high focus on their use and research.[11,12]

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