Abstract
Objective: Results obtained from literature reviews and human studies have shown the analgesic effects of clove plant in toothache. The present work was undertake n in order to investigate the possible analgesic effect of clove oil in mice. Materials and Methods : Fifty mice were divided into 5 groups: 1) Saline; 2) Essential oil (Ess) 2%, 3) Ess 5%, 4) Ess10% and 5) Ess 20%. The hot plate test (55±0.2 °C; Cut-off 60 sec) was performed as a base record 15 min before injection of drugs (Saline or 2, 5, 10 and 20% concentrations of Essential oil) and consequently r epeated every 15 minutes after injection. Results: Repeated measures ANOVA test showed that maximal percent effect (MPE) in animal groups treated by 5, 10 and 20% essential oil was s ignificantly higher than saline group. Comparison between 4 treated groups showed that MPE in 10% essential group was higher than 2 and 5% groups however; there was no significant dif ference between 10% and 20% groups. Conclusion: The result of present study showed that clove esse ntial oil has analgesic effect inmice using hot plate test. More investigations are neede d to elucidate the exact mechanism (s).
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
