ANALGESIC EFFECT OF BRYOPHYLLUM PINNATUM L AND CURCUMA XANTHORRIZA COMBINATION ON MICE'S INDUCED BY FORMALDEHYDE AS ARTHRALGIA AGENT

Abstract

Arthralgia is pain in arthritis. Its prevalence is widespread and increasing every year and greatly affect quality of life. Bryophyllum pinnatum L (BP) leaves and Curcuma xanthorriza (CX) rhizomes potensially as antioxidant, analgesic and anti-inflammatory.In this study we examined the analgetic effects of both ethanolic BP and CX extract's combination on the analgetic score using formaldehyde induced.Male mice strain balb/c were divided into 7 groups (n=7), consists of control group (aquadest),aspirin group at a dose of 100mg/ mL,ethanolic extract group with various doses at 200mg/kg BB, p.o. Each group was induced by 0.05 ml Formaldehyde (2.5%) on day. Early phase nociceptive responses were measured in the first 5 minutes and late phase was measured at 15-30 minutes after formaldehyde induced.The analgetic score were determined on early phase and late phase,and then analyzed using ANOVA test.The results showed that the combination of BP and CX extract have analgesic activity in male mice's were induced by formaldehyde. Dose combination of BP and CX with a dose of 100:0 significantly showed optimum analgetic score.The results suggest that BP extract had analgetic activities that should be further examined and potentially candidate as exploited for arthralgia therapies