Analgesic Effect and Safety Evaluation of Dexmedetomidine Combined With Propofol in Patients Undergoing Laparoscopic Cholecystectomy

Abstract

To investigate the analgesic effect and safety of Dexmedetomidine compounded with propofol in laparoscopic cholecystectomy patients. 136 patients who underwent elective laparoscopic cholecystectomy from June 2018 to June 2020 in our hospital were selected, and all patients were classified into Class I~II according to the American Society of Anesthesiologists classification, and were divided into control group and observation group according to the random number table method, with 68 patients in each group. The patients in the observation group were first injected with Dexmedetomidine hydrochloride 1 μg/kg intravenously and then propofol 2 mg/kg intravenously for about 10 min. the patients in the control group were treated with placebo, i.e. 5 ml of 0.9 % saline intravenously followed by propofol 2 mg/kg intravenously. The postoperative recovery of the 2 groups was compared; a simple mental status scale score to evaluate the postoperative cognitive function changes; S100 calcium-binding protein B and oxidative stress indexes were measured in patients before and after surgery. The differences in heart rate, mean arterial pressure and blood oxygen saturation between the two groups at T0 were not statistically significant (p>0.05); at T1, heart rate and mean arterial pressure of the two groups were significantly lower than those at T0 (p<0.05), and the differences in heart rate and mean arterial pressure between the observation group and the control group at T1 were statistically significant. Significance (p<0.05). However, there was no statistically significant difference in blood oxygen saturation between the two groups at different time points (p>0.05). After the administration of blood oxygen saturation, the mean onset of effect time, time of awakening and the dosage of propofol in the observation group were significantly less than that in the control group (p<0.05). The simple mental status scale scores were significantly higher in the observation group than in the control group at 6 h, 12 h and 24 h after surgery, and the difference was statistically significant (p<0.05); S100 calcium-binding protein B was significantly lower in the observation group than in the control group at 24 h after surgery, and the difference was statistically significant (p<0.05); postoperative superoxide dismutase, malondialdehyde, and malondialdehyde were significantly higher in the observation group than in the control group (p<0.05). The total antioxidant capacity was significantly increased, and the total antioxidant capacity was significantly decreased (p<0.05); the postoperative superoxide dismutase and malondialdehyde were significantly lower than those of the control group, and the total antioxidant capacity was significantly higher than that of the control group, and the difference was statistically significant (p<0.05). Laparoscopic cholecystectomy using propofol compounded with Dexmedetomidine can significantly reduce oxidative stress, reduce brain tissue damage, and protect patients’ cognitive function, with satisfactory resultsy.