Abstract
As a widely used clinical biomedicine for movement disorders and anti-wrinkle, in recent years, BoTN/A has emerged as a potential approach for treating refractory pain, especially migraine, diabetic pain, postherpetic neuralgia (PHN). In this study, we compared the analgesic effect of diverse administrations of Botulinum neurotoxin A (BoTN/A) on rat partial sciatic nerve ligation (PSNL) neuropathic pain model. Single intraplantar (i.pl.) and intrathecal (i.t.) injection of BoTN/A was applied after or before PSNL operation, respectively. The nociceptive behavioral tests showed single intraplantar injection after or before operation, limitedly blocked PSNL induced m echanical and thermal hypersensitivity, even at quite high dose (40U/kg). However, single BoTN/A intrathecal injection low dose (1U/kg) at 2 days previous operation, prevented the neuropathic pain initiation and facilitated functional recovery. These results indicated intrathecal pre-administration of BoTN/A has opportunity to be approved as preventive medication in clinical application.
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