Analgesic-associated nephropathy. Unappreciated cause of renal dysfunction.

Abstract

Analgesic-associated nephropathy is a preventable renal disease that leads to end-stage renal failure when it is not recognized and treated. Patients with this disorder are usually evaluated initially by the family physician, whose awareness of the entity and high degree of clinical suspicion will result in specific questioning regarding analgesic intake. A history of analgesic abuse, coupled with associated laboratory and radiologic abnormalities, usually suffices to make the diagnosis. A favorable prognosis is dependent on early diagnosis and discontinuation of all analgesic use.