Abstract
Pain and inflammation are associated with the pathophysiology of different clinical conditions. The Lysimachia capillipes Hemsl. capilliposide (LCc) is the main bioactive component of this Chinese medicinal herb, which is widely used as a remedy for the treatment of colds and arthritis. This study investigated the analgesic and antiinflammatory activities of LCc in an animal model. LCc had no significant influence on the spleen, lung, liver and stomach coefficients in mice. Pharmacological studies showed that LCc at all doses (40, 60 and 90 mg/kg) increased the latency period of paw licking induced by thermal stimulation, and at the dose of 40 mg/kg it significantly suppressed abdominal writhing episodes of mice induced by intraperitoneal (i.p.) injection of acetic acid. LCc also had antiinflammatory effect on inflammation models. Doses of 60 and 90 mg/kg suppressed paw edema induced by subcutaneous (s.c.) injection of carrageenan. Mechanistic studies revealed that the antiinflammatory effect of LCc was associated with inhibition of the production of malondialdehyde (MDA), prostaglandin E2 (PGE2), tumor necrosis factor (TNF-?), cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) in paw tissue of carrageenan-injected mice. These results show that LCc has analgesic and antiinflammatory effects in mice.
Highlights
Pain and inflammation are common manifestations of many diseases and are elements of the complex response of the body to harmful stimuli [1,2]
The expression of COX-2 is maximal at the late phase [13], and it has been proposed that free radicals play an important role in carrageenan-induced acute inflammatory response
Our results clearly showed that the coefficient to be one of the proinflammatory mediators of the of the kidney of mice treated with 90 mg/kg of Lysimachia capillipes Hemsl. capilliposide (LCc) carrageenan-induced inflammatory reaction, and it can induce a further release of kinins and leukotrienes with a possible role in the maintenance of a long-lasting nociceptive response [58]
Summary
Pain and inflammation are common manifestations of many diseases and are elements of the complex response of the body to harmful stimuli [1,2]. Inflammation is a beneficial host response of the body that induces physiological adaptations to minimize tissue damage by removing the classic initiators of inflammation, such as pathogens, chemicals or physical tissue injury [6]. TNF-α, a proinflammatory mediator, plays an important role in the development of inflammation and oxidative stress [9]. The expression of COX-2 is maximal at the late phase [13], and it has been proposed that free radicals play an important role in carrageenan-induced acute inflammatory response
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