Abstract
Objective:To study analgesic and anti-inflammatory activities of a methanolic extract (ME) of Argyreia speciosa (AS) root powder.Materials and Methods:The study was carried out using male albino mice (20-25 gm) and male wistar rats (100-150gm). The ME was prepared using soxhlet extraction process. The effect of ME of A. speciosa was investigated for analgesic activity using acetic acid-induced abdominal constriction, tail immersion method and hot plate method. The anti-inflammatory activity of ME of AS roots was studied using carrageenan-induced rat paw edema.Result:The ME of A. speciosa root was used in pain and inflammation models. The analgesic activity of AS at the dose of (30,100, and 300 mg/kg p.o) showed significant (P<0.01) decrease in acetic acid-induced writhing, whereas ME of A. speciosa at the dose of (100, 300 mg/kg p.o) showed significant (P<0.01) increase in latency to tail flick in tail immersion method and elevated mean basal reaction time in hot plate method. The ME of the A. speciosa at doses (30, 100, and 300mg/kg) showed significant (P < 0.01) inhibition of carrageenan induced hind paw edema in rats.Conclusion:The ME of A. speciosa showed significant analgesic and anti-inflammatory activity in mice and rat.
Highlights
Phytochemical test The phytochemical screening revealed the presence of alkaloids, resins, carbohydrate, flavonoids, triterpenes, starch, and tannins in methanolic extract (ME) of A. speciosa
Significantly (P < 0.01) reduced the number of abdominal constrictions induced by acetic acid compared to control group
Maximum inhibition of writhing response by ME of A. speciosa (300 mg/kg) was 43.55%, which was comparable to aspirin (20 mg/kg) [Figure 1]
Summary
F. (Convolvulaceae), commonly known as Vridha daraka is a rasayana herb used in many Ayurvedic preparations in the Indian system of medicine. Roots of A. speciosa are used in Ayurveda as an aphrodisiac, rejuvenator, intellect promoting brain tonic, nervine tonic for liver disorders and as a tonic for general debility.[1-3]. Previous investigations on A. speciosa roots have revealed the presence of aryl esters,[4] coumarin glucoside,[5] p-hydroxycinnamate and scopoletin[6] as important phytoconstituents. In Hindu medicine, the root is regarded as an alternative tonic and useful in rheumatic affection and disease of the central nervous system. The plant has been reported to possess antimicrobial,[6] anti-inflammatory, wound healing,[7] immunomodulatory[8] and nootropic[9] activities. This study was undertaken to evaluate the analgesic and anti-inflammatory properties of methanolic extract of A. speciosa in mice and rats at different doses
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