Abstract
Introduction: Bubonium graveolens is used in traditional pharmacopoeia against imbalances of the gastrointestinal tract, cephalic pains, and bronchitis, and as an anti-inflammatory agent.
 Methods: We have investigated the analgesic and anti-inflammatory activities of the aqueous extract of Bubonium graveolens in male mice of strain NMRI Albinos, weighing between 22 g and 38 g. Acetic acid was used to induce writhes in the mice and inflammation of paw edema.
 Results: Evaluation of the analgesic activity showed that the aqueous extract at 150 mg/kg of the plant induced a decrease in the number of abdominal cramps caused by 1% acetic acid. The aqueous extract of the plant had an analgesic effect almost equal to that of Diclofenac; in fact, the latter caused a pain inhibition of 49 ± 1.1% while Bubonium graveolens caused a pain inhibition of 49.6 ± 2.1%, at the concentration of 150 mg/kg. Evaluation of the percentage of inhibition showed that the aqueous extract of Bubonium graveolens had a better anti-inflammatory activity compared to Diclofenac sodium during the treatment duration (69.57% — 56.52% at 60 min; 71.43% — 50.00% at 120 min, and 75.00% — 66.67% at 180 min).
 Conclusion: The results of this research indicate that Bubonium graveolens inhibits inflammation and could explain its effective use in traditional medicine.
Highlights
Bubonium graveolens is used in traditional pharmacopoeia against imbalances of the gastrointestinal tract, cephalic pains, and bronchitis, and as an anti-inflammatory agent
The anti-inflammatory effect of aqueous extracts of Bubonium graveolens at a dose of 150 mg/kg has been evaluated in the present study
The results obtained from the antiinflammatory tests show that our aqueous extract of Bubonium graveolens appreciably reduce formalininduced edema
Summary
Bubonium graveolens is used in traditional pharmacopoeia against imbalances of the gastrointestinal tract, cephalic pains, and bronchitis, and as an anti-inflammatory agent. Bubonium graveolens is a medicinal plant growing in arid and semi-arid climates It stretches from the north of Africa to the desert of Central Asia but is widely represented in southwestern Algeria and southern Morocco [1,2]. Bubonium graveolens is used in the treatment of gastrointestinal disorders, fever, cephalic, dietary, and bronchitis, as well as an anti-inflammatory agent [5,6,7]. It was used as a botanical fungicide [8,9] and was reported to possess antimicrobial and hypoglycemic activities [10,11]
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