Abstract
Background. Inflammation and pain are closely related to humans' and animals' health. Resveratrol (RSV) is a natural compound with various biological activities. The current study is aimed to evaluate the analgesic and anti-inflammatory activities of RSV in vivo. Materials and Methods. The analgesic effects were assessed by the acetic acid-induced writhing and hot plate tests. The anti-inflammatory effects were determined using the xylene-induced mouse ear oedema, the acetic acid-induced rat pleurisy, and carrageenan-induced rat synovitis tests, respectively. Results. The analgesic results showed that RSV could significantly inhibit the number of writhes and improve the time and pain threshold of mice standing on hot plate. The anti-inflammatory results showed that RSV could inhibit the ear oedema of mice. In acetic acid-induced pleurisy test, RSV could significantly inhibit the WBC and pleurisy exudates, could decrease the production of NO, and elevate the activity of SOD in serum. In carrageenan-induced synovitis test, RSV could reduce the content of MDA and elevate the T-SOD activity in serum; RSV could inhibit the expressions of TP, PGE2, NO, and MDA. Conclusion. Shortly, these results indicated that RSV had potent analgesic and anti-inflammatory activities and could be a potential new drug candidate for the treatment of inflammation and pain.
Highlights
Pain and inflammation are implicated in virtually all human and animal diseases, and they are usually produced by physical, chemical, and biological stimuli, or some combination of these [1]
Carrageen was bought from the Sigma Company (USA); nitrogen monoxide (NO), malondialdehyde (MDA), superoxide dismutase (SOD), total superoxide dismutase (T-SOD), prostaglandin E2 (PEG2), and total protein (TP) kits were all bought from Nanjing Jiancheng Bioengineering Institute (Nanjing, China)
Due to the presence in virtually all human and animal diseases, inflammation and pain have become the focus of global scientific research, while current analgesics and nonsteroidal anti-inflammatory drugs (NSAIDs) have several adverse effects during the treatment process [18, 19]
Summary
Pain and inflammation are implicated in virtually all human and animal diseases, and they are usually produced by physical, chemical, and biological stimuli, or some combination of these [1]. The analgesic effects were assessed by the acetic acid-induced writhing and hot plate tests. The anti-inflammatory effects were determined using the xylene-induced mouse ear oedema, the acetic acid-induced rat pleurisy, and carrageenan-induced rat synovitis tests, respectively. The analgesic results showed that RSV could significantly inhibit the number of writhes and improve the time and pain threshold of mice standing on hot plate. The anti-inflammatory results showed that RSV could inhibit the ear oedema of mice. In acetic acid-induced pleurisy test, RSV could significantly inhibit the WBC and pleurisy exudates, could decrease the production of NO, and elevate the activity of SOD in serum. These results indicated that RSV had potent analgesic and anti-inflammatory activities and could be a potential new drug candidate for the treatment of inflammation and pain
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