ANALGESIC ACTIVITY OF SOME NEW SYNTHETIC DIBENZO-α-PYRONES DERIVATIVES

Abstract

Following standard Hurtley reaction, by using 2 - Bromobenzoic acid, resorcinol and NaOH in the presence of CuSO 4 solution as a catalyst, a clay coloured solid of dibenzo - α - pyrone was prepared. This resulting solid of DBαP was then reacted with various amines respectively, formaldehyde and ethanol and refluxed for 1.5 h as per Mannich reaction resulting into eleven new synthetic Mannich der ivatives of DBαP. The characterisation of synthesised new compounds were done by various spectral (UV, IR and NMR) and analytical methods. The synthesised derivativ es were also evaluated for their analgesic activity using different animal models ( Tail clip test and Hot plate method). Some of these compounds exhibit ed promising activities.