Abstract
Transcutaneous electrical stimulation was employed at two sites in the second trigeminal division to induce dental analgesia in 24 human subjects who were undergoing painful tooth pulp stimulation. Injection of either 1 ml (0.4 mg) naloxone or 1 ml saline was given to each volunteer after 20 minutes of stimulation under double blind conditions. Saline subjects showed no loss of analgesia while naloxone subjects had a partial and significant loss of analgesia. This observation suggests that endogenic opiate-like substances play a role in stimulation-induced analgesia.
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