Abstract
Purpose High-grade anal neoplasia (AN) is associated with highrisk human papillomavirus (HPV) genotypes and is the precursor to anal cancer. Individuals infected with human immunodeficiency virus type 1 (HIV) continue to be at increased risk for AN even while on effective antiretroviral therapy (ART) with undetectable HIV RNA levels. The study was undertaken to assess HIV DNA from anal cytology specimens to determine if HIV DNA copy number was a factor for presence of high risk HPV genotypes.
Highlights
High-grade anal neoplasia (AN) is associated with highrisk human papillomavirus (HPV) genotypes and is the precursor to anal cancer
Anal human immunodeficiency virus type 1 (HIV) DNA is associated with high-risk HPV genotypes in anal cytology specimens obtained for anal neoplasia screening
Analysis was performed by logistic regression model with high HPV risk as the response and HIV DNA copy numbers, anal Pap cytology results, and nadir CD4 cell counts as predictors
Summary
Anal HIV DNA is associated with high-risk HPV genotypes in anal cytology specimens obtained for anal neoplasia screening Purpose High-grade anal neoplasia (AN) is associated with highrisk human papillomavirus (HPV) genotypes and is the precursor to anal cancer. The study was undertaken to assess HIV DNA from anal cytology specimens to determine if HIV DNA copy number was a factor for presence of high risk HPV genotypes. Material and methods Anal cytology specimens were obtained as part of an AN study according to guidelines approved by the local institutional review board.
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