Abstract
Rhinovirus is the most common trigger for asthma exacerbations and causes neutrophilic inflammation. Neutrophilic inflammation and airway mucus in asthma exacerbations are often resistant to effects of glucocorticoids, and there are no specific therapies. Anakinra (IL-1 receptor antagonist) treatment reduces inhaled LPS-induced inflammation in humans. We hypothesize that anakinra treatment will reduce rhinovirus-mediated pro-inflammatory cytokine production from the airway epithelium important for neutrophil recruitment.
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