Abstract
Background: Anacyclus pyrethrum (A. pyrethrum) is a wild species belonging to the family Asteraceae, which is used in traditional medicines. Aim of the study: This work was undertaken to study the chemical composition, analgesic, anti-inflammatory, and wound healing properties of hydroalcoholic extracts of different parts (roots, seeds, leaves, and capitula) of A. pyrethrum. Material and Methods: The phytochemical analysis of the studied extracts was conducted by GC-MS. The analgesic activity was evaluated in mice using acetic acid and formaldehyde methods. The anti-inflammatory activity was tested using the inhibitory method of edema induced in rats. The healing activity of the hydroethanolic extracts was explored by excision and incision wound healing models in rats. Results: The phytochemical analysis of the studied plant extracts affirmed the presence of interesting compounds, including some newly detected elements, such as sarcosine, N-(trifluoroacetyl)-butyl ester, levulinic acid, malonic acid, palmitic acid, morphinan-6-One, 4,5.alpha.-epoxy-3-hydroxy-17-methyl, 2,4-undecadiene-8,10-diyne-N-tyramide, and isovaleric acid. The extracts of different parts (roots, seeds, leaves, and capitula) exhibited promising anti-inflammatory, analgesic, and wound healing effects, with percentages of inhibition up to 98%, 94%, and 100%, respectively. Conclusion: This study might contribute towards the well-being of society as it provides evidence on the potential analgesic, anti-inflammatory, and wound healing properties of A. pyrethrum.
Highlights
The traditional use of medicinal plants as natural remedies against various pathologies has received full attention from the scientific community
Analgesic Activity of Samples Demonstrated by the Acetic Acid Method
The extracts of different parts of A. pyrethrum (L) showed a significant analgesic effect against pain caused by acetic acid compared to the control lot, with an inhibition percentage that ranged from 12%
Summary
The traditional use of medicinal plants as natural remedies against various pathologies has received full attention from the scientific community. Medicinal plants have been considered a promising source of essential raw material for the discovery of natural compounds that are used as subsequent drugs to fight ailments [3]. It is a species belonging to the family Asteraceae, which is indigenous to Morocco, Algeria, and Spain [4,5]. This species includes the two varieties Anacyclus pyrethrum var. Anacyclus pyrethrum (A. pyrethrum) is a wild species belonging to the family. Asteraceae, which is used in traditional medicines. Aim of the study: This work was undertaken to study the chemical composition, analgesic, anti-inflammatory, and wound healing properties of hydroalcoholic extracts of different parts (roots, seeds, leaves, and capitula) of A. pyrethrum
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
