Abstract
ABSTRACT Bovine growth, hormone has been digested with papain. Proteolysis of the protein for 2 hr resulted in no loss of growth promoting activity in the hypophysectomized rat. After 3 hr of papain digestion of bovine growth hormone, only one new major electrophoretic component appeared. Exposure to papain for 6 hr produced no appreciable loss of growth promoting activity. When the papain digested growth hormone was administered to 2 hypopituitary patients, one diabetic and one nondiabetic, there was an anabolic effect in both without evidence of diabetogenicity in either.
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