Abstract
The steroid hormones are lipids in nature, which play crucial roles in several metabolic and behavioral pathways in mammals. Drug therapy uses sterol hormones for treating some disturbances linked with its deficiency; however, the illicit use of these hormones by amateur and elite athletes to enhance performance or body appearance may lead to several health issues. In this study we evaluated the anxious-like behavior and the long-term memory acquisition of male rats undergoing sedentary life-style or physical effort, with or without anabolic-androgenic steroids (ASC) treatment. The results showed a decrease in anxious-like behavioral levels in rats that received ASC treatment associated or not with physical effort, but this treatment did not affect the acquisition of long-term memory at the dose and experimental model assessed.
Highlights
It is well established that testosterone and nandrolone have antagonistic effects on behavior
The literature reports about androgenic hormones and their effects on human tissues but there is a lack of studies linking the long-term memory acquisition and anxiety with the administration schedules of anabolic-androgenic steroids (ASC) adopted by athletes
The sum of score was performed throughout the training session and there was no difference between groups, that is, all individuals were subjected to same stimulus and showed similar behaviors
Summary
It is well established that testosterone and nandrolone have antagonistic effects on behavior. Testosterone seems to be able to decrease anxiety levels and impair the memory acquisition (Skoett, Bandak, Kreilberg, Lauritsen, & Daugaard, 2018). These steroids have been misused throughout the world to improve athletes’ performance (Kanayama, & Pope Jr, 2018). The literature reports about androgenic hormones and their effects on human tissues but there is a lack of studies linking the long-term memory acquisition and anxiety with the administration schedules of anabolic-androgenic steroids (ASC) adopted by athletes. In the present study we used Open Field Test (OF) and Step-down Type Passive Avoidance Test (PA) to detect changes in anxious-like behavior and long-term memory in rats experimental model using an administration schedule of ASC
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