An Updated Review on Psoriasis and Surgery

Abstract

Psoriasis is a chronic inflammatory skin disease with a complex pathogenesis involving the interaction between the innate and adaptive immune systems. The release of antimicrobial peptides (AMPs) by keratinocytes, particularly LL-37 peptides, plays a crucial role in the initiation of psoriatic inflammation. The activation of dendritic cells and distinct T-cell subsets, particularly Th1 and Th17, leads to the formation of scaly plaques in psoriasis. Although most cases are treated with topical or systemic medications, severe forms such as pustular psoriasis and psoriatic arthritis may require surgical management. Surgical procedures aim to relieve symptoms, improve function, and minimize scarring and cosmetic deformities. However, psoriatic patients are at higher risk of post-surgical infections and surgical stress may trigger psoriatic flare-ups. Thus, meticulous post-surgical wound care and psychological support are essential for optimal outcomes.