An Updated Review of the Contribution of Noncoding RNAs to the Progression of Gastric Cancer Stem Cells: Molecular Mechanisms of Viability, Invasion, and Chemoresistance of Gastric Cancer Stem Cells.

Abstract

Gastric cancer (GC) is the leading cause of death and cancer mortality in the world, with poor survival for cases with higher stages of GC. During the past decade, GC stem cells (GCSCs), a group of cancer cells, have been the focus of significant research on cancer. GCSCs have the capability of selfrenewal and are identified to participate in GC development, invasion, chemoresistance, and tumor relapse. Research projects have indicated the main activities of noncoding RNAs in cellular pathways. Micro (mi)RNAs and lncRNAs play important functions in the modulation of different cellular pathways in the post-transcriptional form through their dysregulated expression in several cancers, including GC. In this paper, we highlight the impact of dysregulated expression of micro- and lncRNAs and their downstream transcripts on GCSCs. Data collection on the progression of GCSCs may be beneficial for the introduction of new insights to the GC treatment.