Abstract
The present study was aimed to evaluate and compare the antibacterial activities of Chromolaena odorata (L). leaf and flower extracts (LE and FE) against the wound promoting pathogens (Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans) by a combinatorial in vitro/in silico approach. Both LE and FE was found to demonstrate increase in antimicrobial activity with increase in the concentration of the extracts, however, the activity of FE was found to non-significantly higher than the LE. These minor differences in the inhibitory action can be attributed to the variations in the phytochemical composition. The in silico molecular docking also predicted that the phytochemicals present in the LE and FE exhibited good binding with the target proteins of wound promoting pathogens. The ADME prediction studies also suggested their good pharmacokinetic and drug-likeness properties. From the present investigation, it can be inferred that both the leaves and flowers of C. odorata exhibit antibacterial activity against the wound promoting pathogens, thus aiding in wound healing process.
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