An updated quantitative evaluation of the association between leukaemia risk and XRCC3 Thr241Met polymorphism

Abstract

IntroductionSeveral analyses have been conducted to assess the association between leukaemia risk and XRCC3 Thr241Met polymorphism. However, their results are conflicting. Hence, this comprehensive study was carried out to obtain a more accurate assessment of the association between leukaemia risk and XRCC3 Thr241Met (rs861539) polymorphismMaterial and methodsWe searched Ovid, Chinese Biomedical Literature Database (CBM), China National Knowledge Infrastructure (CNKI), Google Scholar, PubMed database and Excerpta Medica Database (EMBASE) for potential eligible studies published as of July 2020. Pooled odds ratio (OR) and 95% confidence interval (ci) were used in evaluating the strength of the association between Thr241Met polymorphism of XRCC3 and leukaemia, and the p-value less than 0.05 (p < 0.05) was considered as the level of significance.ResultsA total of 17 studies consisting of 7241 controls and 4198 cases met our inclusion criteria. No significant association was observed between leukaemia risk and Thr241Met polymorphism of XRCC3 across the five genetic variants. In our ethnicity subgroup evaluation, we noted a significant association between leukaemia risk and Thr241Met polymorphism of XRCC3 among Caucasians under four genetic models. Furthermore, SNP (rs861539) of XRCC3 has a protective effect among Asians under four genetic models.ConclusionsThr241Met polymorphism of XRCC3 has a protective effect in the Asian population but has oncogenic potential in the Caucasian population.