An updated meta-analysis between the association of XRCC1 Arg399Gln polymorphism and hepatocellular carcinoma risk.

Xiao-Lian Zhang,Yu He,Yan Deng,Xue Qin,Jian Wang,Shi Yang,Yu Lu,Qi-Liu Peng,Li Xie,Shan Li,Tai-Jie Li

doi:10.7314/apjcp.2014.15.7.3273

Abstract

Various studies have evaluated the relationship between X-ray repair cross-complementing group 1 (XRCC1) Arg399Gln polymorphism and hepatocellular carcinoma (HCC) risk, but the conclusions have been inconsistent and underpowered. The purpose of this updated meta-analysis was to examine whether XRCC1 Arg399Gln polymorphism confers susceptibility to HCC. Eligible studies extracted from PubMed, Embase, Cochrane Library, VIP (chinese) and CNKI (chinese) up to November 2013 were included in the study. Pooled odds ratio (OR) together with their 95% confidence interval (CI) were estimated to evaluate XRCC1 Arg399Gln polymorphism and HCC risk. Finally, 21 studies with 4,170 cases and 5,030 controls were involved in our meta-analysis. The results demonstrated that there was significant association between Arg399Gln polymorphism and HCC risk under two contrast models in overall populations (AG vs GG: OR=1.265, 95%CI=1.036-1.545, p=0.021; AA+AG vs GG: OR=1.240, 95%CI=1.021-1.506, p=0.030). In subgroup analyses, significant association was found in Asians (A vs G: OR=1.175, 95%CI=1.013-1.362, p=0.033; AG vs GG: OR=1.317, 95%CI=1.070-1.622, p=0.009; AA+AG vs GG: OR=1.289, 95%CI=1.055-1.575, p=0.013) and Caucasians (A vs G: OR=0.591, 95%CI=0.361-0.966, p=0.036; AA+AG vs GG: OR=0.468, 95%CI=0.234-0.934, p=0.031). The results suggest that XRCC1 Arg399Gln polymorphism may increase HCC risk especially among Asians. However, XRCC1 Arg399Gln polymorphism might act as a protective role against HCC among Caucasians.

Highlights

Hepatocellular carcinoma (HCC) is the fifth most frequent diagnosed cancer in men and the seventh in women respectively, and the third most common cause of cancer-related death worldwide exceeded only by lung cancer and stomach cancer (Ferlay et al, 2010; Jemal et al, 2011)
X-ray repair cross-complementing group 1 (XRCC1) gene is a key DNA repair gene involved in BER, which play an important role in the stability and integrity of the genome and the pathogenesis and development of human cancers (Poehlmann et al, 2010)
Chronic hepatitis B or C, obesity, diabetes, excessive alcohol consumption, pre-existing liver cirrhosis and exposure to aflatoxin B1 have been identified as significant risk factors, there is limited understanding on the molecular mechanisms HCC (Gomaa et al, 2008; Hagymasi et al, 2008; Caldwell et al, 2009; Forner et al, 2012)

Summary

Introduction

Hepatocellular carcinoma (HCC) is the fifth most frequent diagnosed cancer in men and the seventh in women respectively, and the third most common cause of cancer-related death worldwide exceeded only by lung cancer and stomach cancer (Ferlay et al, 2010; Jemal et al, 2011). Background: Various studies have evaluated the relationship between X-ray repair cross-complementing group 1 (XRCC1) Arg399Gln polymorphism and hepatocellular carcinoma (HCC) risk, but the conclusions have been inconsistent and underpowered. Pooled odds ratio (OR) together with their 95% confidence interval (CI) were estimated to evaluate XRCC1 Arg399Gln polymorphism and HCC risk.

Results

Conclusion