An Update on the Use of Orthobiologics Combined with Corrective Osteotomies for Osteoarthritis: Osteotomy Site and Intra-Articular Efficacy

Abstract

The goal of osteotomies is to redistribute load within the affected joint, shifting forces from the pathologic knee compartments to contralateral, well-preserved areas, thereby improving symptoms and delaying the need for joint replacement. Proximal tibial osteotomy (PTO) is most commonly performed to treat varus malalignment of the knee whereas distal femoral osteotomy (DFO) is most commonly utilized to treat valgus deformities. Orthobiologics have substantial potential as an adjunct therapy at the time of osteotomy due to the limited inherent regenerative potential of native articular cartilage and the importance of osteotomy site healing. Given the promising nature of orthobiologics in orthopedic surgery for the treatment of bone and soft tissue damage, the purpose of this review is to give an update regarding the use of orthobiologics in combination with osteotomy procedures.