Abstract
This update of the Duffy (FY) blood group system (Meny GM. The Duffy blood group system: a review. Immunohematology 2010;26:51-6) includes additional variants to the Duffy system (International Society of Blood Transfusion system 8; five anti-gens) identified through molecular studies. The most interesting clinical updates, however, include further evaluation of the roles of the Duffy glycoprotein, also known as the atypical chemokine receptor 1, in malaria and hematopoiesis. The transition to understanding the important role of blood group antigens in homeostasis and disease continues.
Highlights
A description of Duffy (FY) blood group system antigens and antibodies and how this information is used in transfusion management was featured prominently in the original Duffy blood group review published in 2010.1 At that time, the Duffy glycoprotein was known to bind to a variety of chemokines of the CXC and CC classes and was referred to as the Duffy antigen receptor for chemokines (DARC)
A new nomenclature was adopted and approved; DARC is known as atypical chemokine receptor 1 (ACKR1).[2]
Liu et al.[5] believe that human P. vivax likely arose from within the diverse strain of Plasmodium species infecting primates in central Africa. They speculate that this ancestral African P. vivax stock infected humans, gorillas, and chimpanzees until the GATA-1 [Fy(a–b–)] mutation appeared, which seemed to eliminate the infection in humans
Summary
This update of the Duffy (FY) blood group system The most interesting clinical updates, include further evaluation of the roles of the Duffy glycoprotein, known as the atypical chemokine receptor 1, in malaria and hematopoiesis. The transition to understanding the important role of blood group antigens in homeostasis and disease continues. To increase as the use of molecular methods for blood typing patients and donors becomes more widespread. The total number of variants remains small (
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