Abstract
This update of the Chido/Rodgers blood group system (Mougey R. A review of the Chido/Rodgers blood group. Immunohematology 2010;26:30-8) summarizes the current understanding of the genetics and serology of this blood group (of which little has changed since the publication of the first review) in a table format as well as summarizes the gene frequencies and disease association with low copy number of C4A or C4B genes. The International Society of Blood Transfusion (ISBT) has designated the ISBT number 017 to this system and the abbreviation CH/RG for the antigen or antibody notation. There are currently nine antigens in the CH/RG system. A brief discussion on the serologic challenges of detecting the antibodies and of newer information on the disease associations is provided. This review concludes with some speculation on how our understanding of C4 genes may be illuminated by current investigation into complexities of autoimmunity and the role of C4 and its progression to a disease state.
Highlights
A review of the Chido/Rodgers blood group system published in 2010 summarized the discovery of this blood group,[1] with the eventual recognition that Chido/Rodgers antigens were not intrinsic red blood cell (RBC) antigens but were epitopes carried on the C4 component of complement
The International Society of Blood Transfusion has assigned 017 to the Chido/Rodgers blood group system, and nine antigens have been described based on the serology of the antibodies.[1]
The copy number variants (CNVs) seen with C4A and C4B genes has been an important aspect of the determination that a lower or higher C4 gene expression can have a strong association with certain diseases
Summary
This update of the Chido/Rodgers blood group system The International Society of Blood Transfusion has assigned 017 to the Chido/Rodgers blood group system, and nine antigens have been described based on the serology of the antibodies.[1] based on molecular analysis, there are at least 24 alleles for C4A and 27 for C4B.2 These allelic forms include single nucleotide polymorphisms, insertions, deletions, stop codons, and copy number variants (CNVs). Primary role in immune complex clearance (reacts with amino groups of antigen or immune complex)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
