Abstract
A cellular senescence-centric understanding of biological aging and age-related chronic diseases is rapidly emerging. As a result, strategies aimed at mitigating the deleterious aspects of cellular senescence are increasingly becoming desirable. Tea is a globally admired and nutrient-rich beverage that not only refreshes the senses but is also implicated in several health beneficial effects including the extension of organismal healthspan and lifespan. The present review discusses the emerging anti-cellular senescence attributes of tea consumption and provides a perspective that the anti-aging aspects of tea should be studied in the purview of cellular senescence. Current understanding of the integrative effects of the immune system and gut microbiome on cellular senescence have also been discussed with the rationale of mitigatory effects of tea. Future research directions and recommendations have been provided which may ultimately help augment tea-oriented successful and healthy aging approaches. • A cellular senescence-centric theory of aging is rapidly emerging. • Tea polyphenols can affect the development and removal of senescent cells. • Tea polyphenols can suppress DNA damage, mitigate SASP and maintain telomere length. • Immunostimulating attributes of tea consumption during aging are also known. • Tea phenols act as second-generation prebiotics and modulate gut dysbiosis during aging.
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