Abstract
Tetanus is a disease caused by the toxin produced by Clostridium tetani, a Gram negative anaerobic spore forming bacillus. Infection acquired from body piercing and puncture wound; intravenous drug abuse, surgical interventions, septic abortion and through infected umbilical stump. After inoculation C.tetani transform into a vegetative rod shaped bacterium and produces metalloproteases such as tetanospasmin and tetanolysin. Tetanospasmin is responsible for painful muscle rigidity and autonomic instability via inactivating inhibitory neurotransmission. The role of tetanolysin is not known.
Highlights
Tetanus is a disease caused by the toxin produced by Clostridium tetani, a Gram negative anaerobic spore forming bacillus
The incubation period.[2]. The widespread distribution of C. tetani spores in our environment in combination with the lack of herd immunity leads to incidental tetanus infections in nonimmunized individuals.[3]. This case report urges on considering generalized tetanus infection, when confronted with non-immunized man who presented with unexplained oropharyngeal symptoms
Oropharyngeal symptoms in generalized tetanus is very rare and is reported in two case reports. [4,5] In both cases, the patients presented with isolated symptoms of dysphagia and trismus, and generalized tetanus infection was recognized later
Summary
Tetanus is a disease caused by the toxin produced by Clostridium tetani, a Gram negative anaerobic spore forming bacillus. Infection acquired from body piercing and puncture wound; intravenous drug abuse, surgical interventions, septic abortion and through infected umbilical stump. After inoculation C.tetani transform into a vegetative rod shaped bacterium and produces metalloproteases such as tetanospasmin and tetanolysin. Tetanospasmin is responsible for painful muscle rigidity and autonomic instability via inactivating inhibitory neurotransmission. The role of tetanolysin is not known.[1]
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