Abstract
We describe a rare presentation of diffuse large B-cell Lymphoma (DLBCL) with recurrent episodes of syncope. During the workup for syncope, the patient was incidentally found to have an extensive mass in the left thorax, which was later diagnosed as stage 2 bulky disease DLBCL. This is the rare case of lymphoma presenting as recurrent syncope without cardiac involvement. The patient did not have any further episodes of syncope after her successful treatment of DLBCL.
Highlights
Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin’s lymphoma (NHL) that accounts for about 30% of adult lymphoma [1]
During workup for syncope, the patient was incidentally found to have an extensive mass in the left thorax, which was later diagnosed as DLBCL
A few cases have been reported, and most of these cases were from patients with recurrent head and neck cancer [2, 3] or lung cancer [8]
Summary
Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin’s lymphoma (NHL) that accounts for about 30% of adult lymphoma [1]. Malignancy presenting as syncope is rare, but a few numbers of cases have been reported in tumors involving the neck [2, 3]. Most of these reported cases were in patients with recurrent head and neck cancer. Syncope from DLBCL without cardiac involvement, despite its frequent cervical involvement, has been only reported in 3 cases far to our knowledge [4–6]. We present an unusual case of a patient who presented with recurrent episodes of syncope without other complaints. During workup for syncope, the patient was incidentally found to have an extensive mass in the left thorax, which was later diagnosed as DLBCL. The patient did not have any further episodes of syncope after her successful treatment of DLBCL
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