An Unusual Form of Avellino Dystrophy after Laser in situ keratomileusis: A Late Onset or Recurrence?

Kyung-Sun Na,Man Soo Kim

doi:10.4172/2155-9570.1000172

Abstract

Purpose: To report an unusual manifestation of a corneal deposit of Avellino corneal dystrophy (ACD) after bilateral, simultaneous laser in situ keratomileusis (LASIK). Methods: A 36-year-old Korean woman who underwent uncomplicated, bilateral LASIK and repeated phototherapeutic keratectomy (PTK) in her left eye due to corneal opacities, showed numerous, fine, white opacities with central corneal stromal haze in the left eye, which was the typical manifestation of the recurrent form of ACD. However, in the right eye, several discrete white opacities were deposited in the central anterial stroma, which was a morphologic feature of the natural course of ACD. Results: The heterozygous R124H (CGC→CAC) mutation of the BIGH3 gene was found in her genomic DNA extraction. Conclusion: Further studies should be focused on what is responsible for the differences of the onset period and the shapes of the deposits in patients with ACD.

Highlights

Granular dystrophy type II (Avellino corneal dystrophy, ACD) is an autosomal dominant corneal stromal disease that shares features of both granular and lattice corneal dystrophies
Recent studies have shown that laser in situ keratomileusis (LASIK) aggravates corneal deposits in patients with exacerbated ACD and so LASIK shoud be avoided in these patients [5,6,7,8]
We report here on an unusual manifestation of a corneal deposit of ACD after bilateral, simultaneous LASIK

Summary

Introduction

Granular dystrophy type II (Avellino corneal dystrophy, ACD) is an autosomal dominant corneal stromal disease that shares features of both granular and lattice corneal dystrophies. We report here on an unusual manifestation of a corneal deposit of ACD after bilateral, simultaneous LASIK. Decreased visual acuity occurred 24 months after LASIK surgery, and two additinal phototherapeutic keratectomy (PTK) procedures were done in her left eyes at the same clinic.

Results

Conclusion