Abstract

Acute Suppurative Thyroiditis (AST), an infection of the thyroid caused by bacteria, fungi, or parasites, is a unique cause of thyroid disease. While the causative agents are usually gram-positive skin flora, cases due to atypical bacteria or fungi have been seen in susceptible patient populations. In adults, AST is usually attributed to trauma, fine needle aspiration of the thyroid, or an immunocompromised state usually due to organ transplant, HIV infection, or uncontrolled diabetes. If untreated, the morbidity and mortality of AST is high. We describe a case of AST in a patient whose only risk factor was uncontrolled type 2 diabetes mellitus where the presumed causative agent was extended-spectrum beta-lactamase producing E. coli, an exceedingly rare cause of AST. We discuss the commonly reported etiologies, risk factors, and hormonal dysfunction of this rare condition.

Highlights

  • It is unusual to implicate the thyroid gland as a source of severe bacterial infection

  • [1] This is in contrast to the more commonly encountered subacute thyroiditis and chronic thyroiditis, known to have viral and autoimmune etiologies, respectively

  • Our patient’s only risk factor was uncontrolled type 2 diabetes mellitus, which has been documented in the literature as a significant risk factor. [3]

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Summary

Introduction

It is unusual to implicate the thyroid gland as a source of severe bacterial infection. A 78-year-old Salvadoran female presented with a 7-day history of fever, sore throat, and tender left-sided neck swelling. Computed tomography (CT) of the neck with contrast showed several gas pockets with fat stranding in the thyroid bed area (Figure 1). The patient was initially given 2 liters of intravenous normal saline, followed by 0.45% normal saline and continuous insulin infusion. Culture of the necrotic tissue grew extended spectrum beta-lactamase (ESBL) producing E. coli, sensitive to ertapenem. 50 micrograms (mcg) daily of levothyroxine was initiated, which was increased to 100 mcg after 3 weeks She did not exhibit any clinical signs of hypothyroidism such as bradycardia or hypotension. On day 24, the patient was discharged to a rehabilitation facility

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