An Unusual Case of Invasive Kaposi's Sarcoma with Primary Effusion Lymphoma in an HIV Positive Patient: Case Report and Literature Review.

Alexandra Millet,Sanmeet Singh,Babak Shokrani,Kim Ann Dang,Genelle Gittens-Backus

doi:10.1155/2015/789616

Alexandra Millet, Sanmeet Singh + Show 3 more

Open Access

https://doi.org/10.1155/2015/789616

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Abstract

We report a case of AIDS-related Kaposi's sarcoma (KS) with Primary Effusion Lymphoma (PEL) in a 28-year-old, African American male. Kaposi's sarcoma is an AIDS defining disease and typically will disseminate early in the course of the disease affecting the skin, mucous membranes, gastrointestinal tract, lymph nodes, and lungs. This case reports an unusual presentation of the disease along with primary effusion lymphoma. Although the most common organ systems affected by KS are the respiratory and the gastrointestinal systems, the lungs of this patient did not show any evidence of KS. Additionally, the patient demonstrates the rarely seen liver and unique pancreatic involvement by KS along with unusual synchronous bilateral pleural and peritoneal cavity involvement by PEL, adding to the distinct pattern of invasive AIDS-related Kaposi's sarcoma.

Highlights

Kaposi’s sarcoma is a tumor caused by Human Herpesvirus8 (HHV-8), known as Kaposi’s sarcoma associated herpesvirus (KSHV) [1]
We report a case of a noncompliant AIDS patient who died from pneumonia and was later found to have an unusual presentation of AIDS-related Kaposi’s sarcoma with primary effusion lymphoma
Kaposi’s sarcoma is the fourth most common malignancy associated with a viral infection [4]

Summary

Introduction

Kaposi’s sarcoma is a tumor caused by Human Herpesvirus (HHV-8), known as Kaposi’s sarcoma associated herpesvirus (KSHV) [1]. It was originally described in the 1980s by Moritz Kaposi, a Hungarian dermatologist, and has widely become known as one of the AIDS defining diseases [2]. Infection of an HIV patient by HHV-8 provides the setting for the development of another AIDS-related disease, Primary Effusion Lymphoma (PEL). We report a case of a noncompliant AIDS patient who died from pneumonia and was later found to have an unusual presentation of AIDS-related Kaposi’s sarcoma with primary effusion lymphoma

Case Presentation

Discussion