Abstract
To describe a patient who developed an unusual polyneuropathy after treatment with interferon alfa-2a for hepatitis C and to discuss issues related to diagnosis and pathogenesis. Case report. Tertiary care center. A 46-year-old man with chronic hepatitis C had acute onset of an axonal polyneuropathy with prominent small-fiber involvement shortly after completing a standard 6-month course of therapy with low-dose interferon alfa-2a. Further interferon treatment for hepatitis C was discontinued. Standard, low-dose interferon alfa-2a treatment can produce a persistent predominantly small-fiber polyneuropathy.
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