Abstract
Some 55 years ago, English physician ATW Simeons1 proposed to treat obesity by administering human chorionic gonadotropin (hCG). Simeons’ protocol involves a combination of up to 6 weeks of a daily low-dose hCG injection and a very-low-calorie-diet (500 kcal per day). Early hCG clinical trials showed mixed results for weight loss; however, in recent decades several randomized controlled trials demonstrated that hCG was no better than placebo, and experts concluded that hCG has no merit for weight loss.2 Thus, the use of hCG for weight loss is discouraged by legitimate clinicians who treat obese patients.3
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