Abstract
There is a notable absence in the practical inorganic curricula for experiments in which students can synthesize and characterize series of inorganic complexes. This is possibility attributed to the long required time which is not normally available in regular lab sessions. To address this absence, this paper describes a two-part experiment for chemistry major students in which they prepare series of metalloporphyrins using microwave-assisted technique. In addition to its attractive simplicity, microwave-assisted preparation substantially reduces the needed reaction time to suit the lab session duration. The first lab session is dedicated to the characterization of the 5,10,15,20-tetraphenylporphyrin (TPP) as well as the synthesis of the corresponding Fe(II), Co(II), Ni(II), Cu(II) and Zn(II) complexes. The second session involves the spectroscopic characterization (UV-vis, 1H-NMR, and IR) of the prepared metalloprophyrins. The students relate the experimental results with the provided theoretical data based on quantum chemical calculations.
Highlights
Since metalloporphyrins play an essential role in the chemistry of the living entities [1,2,3], scientists have always found them fascinating to study, understand, and mimic
Thin-layer chromatography (TLC) was performed on silica gel glass plates (Silica gel, 60 F254, Fluka) and spots were visualized under UV lamp
We are introducing students with microwave-assisted technique as a synthetic tool which is becoming very popular for synthesizing organic compounds in a quick and clean way
Summary
Since metalloporphyrins play an essential role in the chemistry of the living entities [1,2,3], scientists have always found them fascinating to study, understand, and mimic. Synthetic metalloporphyrins possess substantial significance in our world. To be capable of understanding the detailed biological reactions involved in enzymatic processes, we need biomimetic representatives of these complicated enzymatic molecules. Synthetic metalloporphyrins provide such biomimicry molecules; and nowadays, they play important roles in medicine [4] materials [5] catalyst [6] among others. With the advances in microwave-assisted synthesis technique, it is possible to reduce the experimental time substantially
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