An Uncommon Osseous Frontal Sinus Tumor: Monostotic Paget’s Disease

Varant Labajian,Shaun J Kilty,Evie Landry,Chi Lai,Fahad Alfawwaz

doi:10.1155/2013/650428

Abstract

Paget's disease of the bone is a disorder characterized by abnormal breakdown and formation of bone tissue. The cause is believed to be either viral or genetic in origin. Most of the time, patients are asymptomatic. Diagnosis is supported by findings from multiple modalities including serum markers, imaging, bone scans, and histology. We present a rare case of Paget's disease of the bone involving the frontal sinus. We review the relevant clinical, diagnostic, and histological findings. We also suggest indications for the management of monostotic Paget's disease of the frontal sinus.

Highlights

Paget’s disease of the bone (PDB), first described in 1877 by the English surgeon Sir James Paget, has been defined as a disorder of bone remodeling
We present a rare case of Paget’s disease of the bone involving the frontal sinus
The disease can affect any bone in the body, PDB has a predilection for the axial skeleton with skull involvement being the fifth in order of frequency [1]

Summary

Introduction

Paget’s disease of the bone (PDB), first described in 1877 by the English surgeon Sir James Paget, has been defined as a disorder of bone remodeling. The diagnosis of PDB can be made based on multiple modalities including elevated serum alkaline phosphatase, urinary markers, radiologic findings, radionuclide bone scans, and pathology. PDB involves a single bone (monostotic) in 10–35% of cases, but a multifocal (polyostotic) presentation affecting 2 or more bones is more common. The disease can affect any bone in the body, PDB has a predilection for the axial skeleton with skull involvement being the fifth in order of frequency [1]. We report an extremely rare case of PDB of the frontal sinus

Case Report

Discussion

Findings

Conclusion