Abstract
Rat liver homogenates were separated, using a density gradient, into light and heavy subfractional layers of floating lipids. The lighter layer consisted mainly of membrane-free lipid globules ranging in size from 70 nm to 5 μ m in diameter. Membrane-enclosed particles approximately 0.4 μ m in diameter and membrane-free particles of VLDL size were the main components of the heavy subfraction. The membrane-enclosed particles probably are Golgi-derived dense bodies, lipolysosomes, liposomes, and lipids bound to membranous structures. After ethanol administration, Golgi-derived dense bodies increased in number, whereas other structures remained unchanged. The number of Golgi-derived dense bodies increased before any fat infiltration could be detected microscopically in the hepatocytes and it began to decrease before fat infiltration reached its maximum at 16 hr.
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