Abstract
Homozygous loop-tail (Lp/Lp) mice exhibit defects in the otocyst as well as extensive neural dysraphism. At 19 days of gestation, cells in the otic pit of abnormal embryos are flattened and lack the rounded luminal contours characteristic of otic cells in their normal littermates. Apical filaments also are not as prominent as in normal embryos, and there is an increase in densely stained globular material in cells at the ventral lip of the otic pit. With glutaraldehyde-tannic acid fixation, the basal lamina of the otic pit cells shows differences from that of the normal otic pit. In abnormal specimens, the lamina densa is irregular and clumped, and the adjacent less dense area is spotty and lacks the more uniformly arranged and delicate fibrils characteristic of the normal basal lamina. These defects may reflect faulty developmental interactions between the dysraphic neural tube, mesenchymal cells, and otic anlage.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.