Abstract
An ultra-sensitive method for detection of UO22+ was developed based on MoS2 nanosheet and the principle of entropy-driven amplification. UO22+-specific DNAzyme was cleaved to release DNA fragments. The cyclic amplification reaction was initiated by the DNA fragment, and DNA with the fluorophore in the DNA complex is released. MoS2 has a high affinity for ssDNA, but a low affinity for dsDNA. The ssDNA with fluorophore binds to MoS2 based on this characteristic, and the fluorescence intensity is greatly reduced. The degree of fluorescence intensity change has a linear relationship with UO22+ in the range of 10–100 pM, and the detection limit is 3.6 pM. This method has been successfully applied to the detection of UO22+ in water samples and has shown certain potential in the prevention and control of environmental pollution.
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