An RCT of Bupivacaine Liposome Injectable Suspension for Supracervical Hysterectomies Postsurgical Analgesia [06B

Abstract

INTRODUCTION: To demonstrate utilization of intracervical block in reducing postoperative pain for minimally invasive supracervical hysterectomy. METHODS: This study is a randomized double blind placebo controlled study of women who underwent minimally invasive supracervical hysterectomy between October 2018 to April 2019. The severity of pain was assessed preoperatively in the holding area, PACU arrival, 12, 24, and 48 hours postoperatively using a numeric rating scale (NRS) at rest for pain with 0=no pain and 10=worst possible pain. Secondary endpoints were number of patients who required NSAIDS and acetaminophen and break through (additional) opioid analgesic medications at 24 and 48 hours. RESULTS: Of the 60 participants, half were randomized into the control and intervention groups. Immediate post-operative pain scores were 1 and 1.75 (P=.89) in the control and intervention groups respectively. Follow up pain scores were 3 and 3.5 (P=.85) at 12 hours, 3.5 and 5 (P=.22) at 24 hours, and 2.75 and 4 (P=.18) at 48 hours. Secondary outcomes demonstrated 13 and 15 patients used narcotics in the control and intervention groups respectively. Within the first 24 hours, 10 patients in the control and 14 patients in the intervention group used narcotics. Between 24 to 48 hours, 6 and 8 patients in the control and intervention groups used narcotics respectively. CONCLUSION: There was no statistically significant difference in pain scores in the immediately postoperative, 12, 24, and 48 hour time period between the intervention and control groups.