Abstract
Bacteria that form sticky material around the surface and aggregate into matrix with each other are known as biofilms. They comprises different components like clumps of microbes, their flocculants and porous material in which they adhere and form a unique structure. Only some natural multicellular communities have ability to produce the biofilms. Biofilm is a sticky material, and it is organized by microand macro-colonies that cannot be easily removed without rinsing. At first stage of attachment, bacteria produce extracellular polymeric substances (EPS). In some cases, biofilm formation is not considered as a good property of bacteria. Therefore, some antibiofilm formation approaches (Enzyme action, Photodynamic therapy, Nanoparticles and Aptamers) are utilized to stop this process. Production of antibiofilm formation agents with antibacterial activity is the most significant approach that can be utilized for various purposes.
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