Abstract
Carotenoids and coenzyme Q10 are naturally occurring antioxidant compounds that are also found in human skin. These bioactive compounds have been the focus of considerable research due to their antioxidant, anti-inflammatory, and photoprotective properties. In this review, the current state of the art in the encapsulation of carotenoids and coenzyme Q10 in lipid nanoparticles to improve their bioavailability, chemical stability, and skin absorption is discussed. Additionally, the main findings are highlighted on the cytotoxic and photoprotective effects of these systems in the skin.
Highlights
It is well-recognized that prolonged exposure to ultraviolet (UV) radiation has harmful effects on human skin, which can cause physiological and biological changes on this tissue, such as DNA damage, premature aging, and cancer, among other effects [1,2,3]
From the studies described in this review, it was demonstrated that loading carotenoids and Coenzyme Q10 (CoQ10) into lipid nanoparticles is an attractive strategy to increase the topical effectiveness of these bioactive compounds by improving their bioavailability, chemical stability, and skin absorption
It is important to note that carotenoid stability was affected by nanostructured lipid carriers (NLC) oil content and process temperature
Summary
It is well-recognized that prolonged exposure to ultraviolet (UV) radiation has harmful effects on human skin, which can cause physiological and biological changes on this tissue, such as DNA damage, premature aging, and cancer, among other effects [1,2,3]. E), enzymes (superoxide dismutase, catalase, and glutathione peroxidase), and other compounds (melanin, flavonoids, lipoic acid, selenium, and coenzyme Q10) [4,6]. These antioxidants act as a protective network and possess a synergistic effect. Our review aims to provide an outline about the current state of the art of carotenoids and coenzyme Q10 encapsulation in lipid nanoparticles for topical administration. The main outcomes of the studies reported in the literature are reviewed and, the last section, summarizes the challenges, future perspectives, and findings on topical administration of carotenoids and coenzyme Q10
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