Abstract

Abstract: Different plants are rich in medicinal properties, which nature has provided in abundance for the living beings of this earth. Since the dawn of time, nature has proven to be a rich source of bioactive scaffolds that have been exploited in the creation of pharmaceuticals. Osthole is a natural coumarin derivative and potential bioactive compound found in plants. Herein, we aimed to review the origins, biology and pharmacological profiles of osthole, a plant-derived coumarin that is found in a variety of therapeutic plants, including Cnidium monnieri. Osthole, also called 7-methoxy-8-(3-methyl-2-butenyl)-2H-1-benzopyran-2-one, is a naturally occurring coumarin found to be present in different plants of the Apiaceae family, i.e., Cnidium monnieri and Angelica pubescens. The biological potential of the osthole in medicine has been investigated using a variety of literature databases. This study gathered diverse scientific research data on osthole from various literature sources and analysed, including Scopus, Google Scholar, Web of Science and PubMed. From the collected data, it was found that osthole have potential pharmacological activities, such as anticancer, antioxidant, osteogenic, cardioprotective, antimicrobial, antiparasitic, anti-hyperglycaemic, neuroprotective, and antiplatelet. The data in this review paper supports the pharmacological potential of osthole, but to completely appreciate the pharmacological potential of this therapeutically powerful chemical, researchers must focus their efforts on further experimentation, biosafety profiling and synergistic effects of this compound. The purpose of this study was to learn more about the origins, biology, and therapeutic benefits of osthole in medicine in order to develop better treatments for human diseases.

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