An Overview on Recent Progress in Electrochemical Biosensors for Antimicrobial Drug Residues in Animal-Derived Food.

Akhtar Hayat,Gaelle Catanante,Marjan Majdinasab,Jean Marty,Abdur Rahim,Mustansara Yaqub

doi:10.3390/s17091947

Abstract

Anti-microbial drugs are widely employed for the treatment and cure of diseases in animals, promotion of animal growth, and feed efficiency. However, the scientific literature has indicated the possible presence of antimicrobial drug residues in animal-derived food, making it one of the key public concerns for food safety. Therefore, it is highly desirable to design fast and accurate methodologies to monitor antimicrobial drug residues in animal-derived food. Legislation is in place in many countries to ensure antimicrobial drug residue quantities are less than the maximum residue limits (MRL) defined on the basis of food safety. In this context, the recent years have witnessed a special interest in the field of electrochemical biosensors for food safety, based on their unique analytical features. This review article is focused on the recent progress in the domain of electrochemical biosensors to monitor antimicrobial drug residues in animal-derived food.

Highlights

Human health is greatly influenced by environment, the quality and nature of the food consumed
The incorporation of nanomaterials can potentially increase the response speed, selectivity and sensitivity to meet the requirements of detection of contaminants in food samples [30,31]
The sensor has certain advantages such as selectivity and enough sensitivity for antibiotic detection in foods. Another multiplex detection assay was reported by Chen et al [62]. They developed an electrochemical aptasensor for multiplex detection of chloramphenicol and oxytetracycline using probe-based metal ions encoded with nanoscale metal-organic frameworks (NMOF) as a substrate, and circular strand-replacement DNA polymerization (CSRP) target triggered the amplification strategy

Summary

Introduction

Human health is greatly influenced by environment, the quality and nature of the food consumed. The various antibiotic families used so far in veterinary medicines include sulphonamides, lincosamides, nitrofurans, trimethoprim, amphenicols, tetracyclines, polymyxins and β-lactams and quinolones [3,4,5] Residues of these drug can pose serious health hazards by contaminating food products consumed by humans such as milk, chicken, egg, honey, fish or meat [6]. Keeping in mind the above facts, it is the need of the day to develop reliable screening methods for selective and sensitive monitoring of veterinary drug residue levels in animal derived food to ensure the safe and quality food supply and to curtail their effects on consumers’ health. To date several analytical methods have been developed to determine the drug residue levels in food products originated from animals These methods can be divided into two groups, namely, screening and confirmatory methods. Biosensor technology is not well established for confirmatory tests, these can provide a future tool for screening purposes in the domain of antimicrobial drug residue monitoring

Biosensors as an Alternative Analytical Tool

Synthetic

Kanamycin

Chloramphenicol

Schematic

Tetracycline

Streptomycin

Conclusions and Future Prospects