An Overview on Multiple Emulsions

Abstract

Multiple emulsions are dynamic hetero-dispersed structures in which water concurrently occurs water in oil and oil in water emulsion both controlled by lipophillic and hydrophilic surfactants. The combination of all such surfactants is useful in stabilizing multiple emulsions. Multiple emulsions include water-in-oil-in-water (w / o / w) and oil-in-water-in-oil (o / w / o) type; the former has extensive formulation, preparation techniques, and multiple-emulsion in-vitro analysis methods are checked. With specific reference to multiple emulsions of the w / o / w, different factors influencing the stability of multiple emulsions and stabilize strategies are discussed in detail. It finds wide range of applications in Multiple emulsions in cancer therapy, Multiple emulsions in herbal medicines, Vaccine / adjuvant, Oxygen replacement, Inverse targeting, Multiple diabetes emulsions, Multiple emulsions in food, Drug over doses treatment, etc. In the course of such microencapsulation a few emulsions were also used as an intermediate step in the process of such microencapsulation and are the structures of growing interest in the oral delivery of hydrophilic drugs that become unstable in gastrointestinal tracts such as proteins and peptides. Stability a with developing preparation methods, drug release tests, in vitro release studies, globule size or particle size, stability and rheological characterization of multiple emulsions, will be able to provide a novel carrier mechanism for medicines, cosmetics and pharmaceutical agents.