Abstract
<p>Risk assessment is an important issue for starting medication for patients. Literature reveals that diabetes, hypertension, dyslipidemia and Body Mass Index (BMI) are among major risk factors for longevity. Since the cut-off points proposed in various sources are generally irrespective of age, sex and race, it has been attempted to validate current definitions for Tehran’s elderly population by using a prospective cohort study. For this purpose, one thousand seven hundred and ninety eight (1,798) individuals above 60 years old were recruited in the primary phase of the Tehran Lipid and Glucose Study (TLGS) during 1998-2001, and were tested for their systolic and diastolic blood pressure, total cholesterol, LDL cholesterol, high density lipoprotein cholesterol (HDL), triglyceride (TG), fasting blood sugar (FBS), 2-h plasma glucose (2HPG) and some other factors at the time of entry to the study. They were followed up for 13 years and their vital statuses were registered (1998-2011).</p><p>According to the standard definition of diabetes, dyslipidemia and hypertension, the participants were divided into ill and healthy groups. By using univariate Cox proportional hazard model, a 95% hazard ratio for various risk factors was estimated. Cut-off points of 126 mg/dL for fasting blood sugar or 200 mg/dL for 2HPG for defining diabetes were identified as appropriate points for predicting longevity for elderly males and females. Systolic blood pressure over 140 mmHg or diastolic blood pressure over 90 mmHg or having medication as a definition of hypertension were identified as a significant risk factor for elderly males only. Dyslipidemia which is defined based on Cholesterol&gt;240 or TG&gt;400 or LDL&gt;160 or HDL&lt;35, was not identified as a longevity predictor for elderly men and women. The results showed that BMI&gt;31 Kg/m<sup>2</sup> at the time of entry to the study significantly reduced the survival time of women. In conclusion, the definitions of diseases like hypertension and dyslipidemia based on cut-off points don’t classify the Tehran’s elderly population accurately. More investigation in this regard is required.</p>
Highlights
Classifying people into two groups of healthy and sick, with respect to a particular illness, is usually done on the basis of standard definitions presented in the literature
One thousand seven hundred and ninety eight (1,798) individuals above 60 years old were recruited in the primary phase of the Tehran Lipid and Glucose Study (TLGS) during 1998-2001, and were tested for their systolic and diastolic blood pressure, total cholesterol, LDL cholesterol, high density lipoprotein cholesterol (HDL), triglyceride (TG), fasting blood sugar (FBS), 2-h plasma glucose (2HPG) and some other factors at the time of entry to the study
By using the Tehran Lipid and Glucose Study (TLGS) data, with the aid of the survival analysis method, the aim of this study is to present an overview on cardiovascular risks and re-evaluate the definitions regarding some of the risk factors that reduce lifespan, such as diabetes, high blood pressure, the blood cholesterol level and obesity in Tehranian men and women, in the age group of 60 and over
Summary
Classifying people into two groups of healthy and sick, with respect to a particular illness, is usually done on the basis of standard definitions presented in the literature. According to the literature, in classifying people into groups of healthy and diabetic, if an individual has fasting blood glucose of over 126 mg/dL or 2-h plasma glucose (2HPG) over 200 mg/dL or has a history of using medicine to reduce blood glucose, he or she will be considered “diabetic”; otherwise, that individual will be considered “non-diabetic” (Diabetes Care, 2015). Vol 9, No 4; 2017 pressure, he or she will be considered “hypertensive” (Diabetes Care, 2015). The significance of these definitions lies in the fact that, based on these classifications, treatment of the unhealthy and the administration of medicine is begun by a physician. It is necessary to make a more precise assessment of these definitions within different societies, between men and women, and among various age groups
Sign-in/Register to view highlights & summary 
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
