Abstract
AbstractTetrazoles are distinguished by a five-membered, doubly unsaturated ring which consists of four nitrogen and one carbon atom with a molecular formula CN4H2, which have a wide range of medicinal activity and potential role in biosciences. Interest in tetrazole chemistry in recent decades has been increasing rapidly because of diverse biological and pharmaceutical applications, mostly due to the diversity of this N-heterocyclic moiety in medicinal chemistry. This moiety offers a more appreciative pharmacokinetic profile and plays the role of metabolically stable substitute for carboxylic acid functional group as well as exhibits a broad range of biological effects such as analgesic, antibacterial, anticancer, anti-inflammatory, antidiabetic, antifungal, antitubercular and antihyperlipidemic activities. This chapter highlights the unique features of the potential possible role of tetrazole derivatives and summarizes biological and pharmacological activities.KeywordsTetrazolesN-heterocyclesPharmacophoreDrug discoveryAngiotensinogen
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