Abstract
Annona cherimola Mill., or the custard apple, is one of the species belonging to the Annonaceae family, is widely used in traditional medicine, and has been reported to be a valuable source of bioactive compounds. A unique class of secondary metabolites derived from this family are Annonaceous acetogenins, lipophilic polyketides considered to be amongst the most potent antitumor compounds. This review provides an overview of the chemical diversity, isolation procedures, bioactivity, modes of application and synthetic derivatives of acetogenins from A. cherimola Mill.
Highlights
Annona cherimola Mill., or the custard apple, is one of the species belonging to the Annonaceae family, is widely used in traditional medicine, and has been reported to be a valuable source of bioactive compounds
One of the species that has been used in traditional medicine for a long time and with a valuable source of bioactive molecules is Annona cherimola Mill
Most methods comprise a first phase consisting of the extraction of the dried plant material using methanol, ethanol or dichloromethane as a solvent. This first step is followed by further fractionations by means of different separating chromatographic techniques, including open-column chromatography (OPC), flash chromatography (FC), preparative thin-layer chromatography (PTLC) or high-performance liquid chromatography (HPLC) [37]
Summary
Plants are one of the most important and diverse sources of chemical structures and bioactive compounds. Cherimoyas are considered an exotic fruit native to inter-Andean valleys from Peru and Ecuador [3] They can be found and are commercially cultivated in several mild-temperature regions around the world, such as Portugal, Italy, Taiwan or Spain [4]. Over the last few decades, a growing number of studies have focused on the phytochemical composition of ACM extracts in order to explain their traditional applications and to determine the compounds in ACM that are responsible of its biological activity. Some phytochemicals, such as tocopherols, flavonoids, responsible of its biological activity.
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